Pharmacokinetics of eprinomectin in lactating ewes following administration of a subcutaneous formulation of eprinomectin

Summary

Based on this pharmacokinetic study, subcutaneous administration of Eprecis 2% is expected to be efficacious in sheep for the control of endoparasites at 0.2 mg/kg. At this dose rate, no eprinomectin residue above the MRL was detected in the milk of treated ewes. Moreover, this dose rate was associated with greater bioavailability than the recently registered pour-on formulation which dose rate is 1 mg/kg.