Determination of the fetal protection in pregnant heifers challenged with bovine viral diarrhea type 1 virus twelve months after one administration of a live-attenuated vaccine

Summary

Mucosiffa® (Ceva Santé Animale) is a modified-live vaccine (MLV) used for the control of bovine viral diarrhea virus (BVDV) infection. In pregnant heifers experimentally challenged by BVDV-1, one administration of Mucosiffa® 126 days before challenge had been proven to prevent fetal infection1. Because current practices in cattle farms favors yearly vaccination schedules, a new experiment was carried out to evaluate the level of fetal protection obtained in pregnant heifers challenged twelve months after one administration of Mucosiffa®.

Results demonstrate that Mucosiffa® is a safe MLV that provides 100% fetal protection to breeding females for at least one year after one intramuscular administration.